WP 2. In vitro siRNA application using synthetic carrier systems in cell culture models

WP 3. Lentivirus-mediated siRNA knock down of ENaC in various cell lines and CF human respiratory epithelial cells

WP 4. Analysis of electrophysiologic effects of ENaC downregulation in vitro

WP 5. Aerosol application of siRNA constructs

WP 6. Suppression of ENaC during fetal and postnatal life as a novel strategy for gene therapy

WP 7. In vivo application of siRNA constructs using therapeutic mouse models